Apply Online for Pharma graduates as Government Analyst under Public Service Commission

All candidates are requested to carefully read the Instructions to Applicants available in the Commission’s website tnpsc.gov.in and this Notification. The candidates applying for the examination should ensure that they fulfill all eligibility conditions for admission to the examination. Their admission to all stages of the examination will be purely provisional, subject to their satisfying the eligibility conditions. Mere admission to the written examination / certificate verification / counselling or inclusion of name in the selection list will not confer on the candidates any right to appointment. The Commission reserves the right to reject candidature at any stage, after due process even after selection has been made, if a wrong claim or violation of rules or instructions is confirmed.

Post : Junior Analyst

Name of the Department / Organization : Drugs Control Administration
Number of Vacancies : 05
GT (G) (LV) : 1
MBC/DC (G) (LD/LC/DF/AC) : 1
ST(G) : 1
GT (G) (PSTM) : 1
BC (OBCM) (W) : 1
Level of Pay : Level 16 (CPS)
Post Code : 2006

Qualification and Experience : (i) Must be a graduate in Pharmacy or Chemistry or Pharmaceutical Chemistry and
(ii) Should possess not less than two years experience in the analysis of drugs

(iii) Provided that the requirement of experience may be reduced to one year in the case of Pharmacy graduates and Post Graduates in Chemistry with Analytical Chemistry as a specific subject
Subject Paper & Subject Code
Chemistry - 430
Pharmacy/Pharmaceutical Sciences - 429
Age Limit :(as on 01.07.2024) The candidates should have completed the age of 21 years for all the posts, except for the post of Foreman Marine (Post Code: 1762). For the post of Foreman Marine the candidates should have completed 18 years. The category wise maximum age limit and age concession details are given below:
Others
Maximum Age (Should not have completed) : 32
Age Concession
Persons with Benchmark Disability : 42
Ex- Servicemen : 50
Destitute Widow : No Maximum Age Limit
BC (OBCM)s, BCMs, MBCs/DCs, SCs, SC(A)s and STs :No Maximum age limit
Abbreviations :
BC(OBCM) - Backward Classes (Other than Backward Class Muslims)
BCM - Backward Class Muslims
MBC / DC - Most Backward Classes / Denotified Communities
SC - Scheduled Castes
SC(A) - Scheduled Castes (Arunthathiyars)
ST - Scheduled Tribes
NA - Not Applicable, since persons with benchmark disability are not eligible to apply for this post.
Supporting Documents
1. The date of birth will be verified against the tenth standard (SSLC) or twelfth standard (HSC) mark sheet, issued by the Tamil Nadu Board of Secondary Education and Tamil Nadu Board of Higher Secondary Education respectively.
2. Those candidates whose date of birth is not mentioned in their tenth standard / twelfth standard mark sheet must upload / produce their Birth Certificate / Transfer Certificate/ Degree Mark Sheets, instead of the tenth standard or twelfth standard mark sheet. Any other form of evidence will not be accepted.
3. Failure to upload / produce such a document shall result in the rejection of candidature after due process.

Examination Fee
1. The examination fee of Rs.100 (Rupees One hundred only) should be paid at the time of submitting the online application for this recruitment, unless exemption of fee is claimed.
2. Candidates belonging to special categories can avail of exemption from paying examination fees as per eligibility criteria. For further details refer to Annexure II of this Notification.
3. The total number of free chances availed, will be calculated based on claims made in previous applications. The number of free chances availed by the candidate may be verified by the Commission at any stage of the selection process. In case a candidate makes a false claim for exemption from payment of the application fee by suppressing information regarding his/her previous application(s), his / her candidature shall be rejected after due process and he / she shall be debarred for a period of one year, from appearing for examinations conducted by the Commission.
4. Candidates are directed to carefully choose the option “Yes” or “No” regarding availing of the fee concession. The choice made, cannot be modified or edited after successful submission of the online application. Candidates are advised in their own interest, to keep an account of the number of times fee concession has been availed, irrespective of the information displayed in the <Application History> of the candidate dashboard.

5. An application (irrespective of the post applied for) claiming fee concession will operate to exclude one chance from the number of free chances allowed. Candidates who have availed the maximum number of free chances permitted / candidates who do not wish to avail of the fee concession / candidates who are not eligible for fee concession shall choose the option “No” against the query regarding fee concession. Such candidates shall thereafter pay the requisite fee through the prescribed mode of payment.
6. Failure to pay the prescribed fee in time, along with the online application, will result in the rejection of the application after due process.

Examination Fee Payment
1. After submitting the details in the online application, the candidates can pay the examination fee by online mode through Net Banking / Credit card / Debit card on or before the last date of submission of the online application by choosing the option in the online application. Candidates have to pay the service charges also as applicable.
2. Offline mode of payment if any received in the form of Demand Draft / Postal Order etc. will not be accepted and the applications forwarded with such modes of payment will be summarily rejected and the same will not be returned or refunded.
3. To facilitate payment of fees through the online mode, an additional page of the application format will be displayed wherein candidates may follow the instructions and fill in the requisite details to make payment. There is a possibility of online payment failure. Hence, if the online payment fails, candidates can check the status of the earlier transaction. If the earlier transactions have failed, the candidate shall retry paying the fee again by online mode. In case of online payment failure, the amount debited from the candidate’s account will be reverted to his/her account. The candidates have been given a provision to check the status of the transaction made. If all the attempts / transactions have failed, candidates have to make the payment again. The Commission is not responsible for online payment failure. It is the responsibility of the candidates to ensure that the transaction made by them is successful.
4. After submitting the payment information in the online application format, wait for the intimation from the server. Meanwhile, DO NOT press ‘Back’ or ‘Refresh’ button to avoid payment failure or double payment.
5. If the online transaction has been successfully completed, an Application Number / Applicant ID will be generated. Candidates should note the Application Number / ID for future reference in respect of the recruitment applied for.
6. Tamil Nadu Public Service Commission reserves the right to change the mode of payment at any time.

Syllabus
Paper II – Subject Paper
PHARMACY / PHARMACEUTICAL SCIENCES (Degree Standard) CODE: 429
UNIT I:
1) Historical background and development of profession of pharmacy: History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
2) Calculations: Posology: Dose calculations based on age, body weight and surface area. Pharmaceutical calculations: Percentage solutions, Alligation, Proof sprit and isotonic solutions based on freezing point and molecular weight.
3) Surface & interfacial Phenomenon: Measurement of surface and interfacial tensions, spreading coefficient, surface active agents, HLB Scale, solubilisation and Detergency
4) pH, buffers and isotonic solution: pH determination, applications of buffers, buffer equation, buffer capacity and buffered isotonic solutions.
5) Unit Operations: Size reduction, size separation, mixing, filtration, centrifugation evaporation, drying, distillation, heat transfer, compression and Tablet coating.
6) Coarse Dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspension. Emulsions and theories of emulsification, micro emulsion and multiple emulsion, stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formation by HLB method.

7) Micromeritics: Particle size distribution, mean particle size, number and weight distribution, particle number, methods of determining particle size by different methods, specific surface, methods of determining surface area and derived properties of powders.
8) Pre-formulation studies: Introduction to pre-formulation, goals and objectives, study of physicochemical characteristics of drug substances a. Physical Properties: Crystal & amorphous form, particle size, shape, flow properties, solubility profile (Pka, pH, Partition co-efficient) Polymorphism. b. Chemical properties: Hydrolysis, Oxidation, reduction racemisation, polymerisation. BCS classification of drugs and its significant Application of preformulation considerations in the development of solid, liquid oral and parenteral dosage forms and its impact on stability of dosage forms.
9) Pharmaceutical Excipients – Used in Liquid, Semisolids and solid dosage forms.
10) Quality Control Tests and Evaluation parameters of the following formulations: Solid dosage forms, Semi solids, Liquid dosage forms, Parenteral, Ophthalmic preparation and Pharmaceutical Aerosols.
11) Cosmetics: Formulation and preparation of the following cosmetics preparationsLipsticks, Shampoos, Cold Cream, Vanishing Cream, Tooth Paste, Hair Dyes and Sunscreens.
12) Packaging Material Sciences: Materials used for packaging of Pharmaceutical Products, factors influencing choice of containers, legal and official requirement for containers, Quality control tests for containers and rubber closures.
13) Bio availability and Bioequivalence: Definitions and objectives of Bioavailability, absolute and relative bioavailability, measurement of bioavailability in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance dissolution rates and bioavailability of poorly soluble drugs.
14) Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment models, Non- compartment models, Physiological models, One compartment open model a) Intravenous Injection (bolus) b) Intravenous infusion c) Extra vascular administrations. Pharmacokinetic parameters - KE, T½, Vd, AUC, Ka, CLt and CLR – definitions, methods of elimination, understanding of their significance and application.
15) Good manufacturing practices (GMP)
16) Good Laboratory practices (GLP): Organisation and personnel, Facilities, equipment, Testing facilities operation, Test and control articles, Protocol for conduct of a Nonclinical Laboratory Study, Records and reports, Disqualification of Testing facilities.
17) Warehousing: Good Warehousing practice, Materials Management.
18) Pilot Plant Scale up Techniques: General considerations – including significance of personnel requirements, space requirements, raw materials, Pilot plant scale up considerations for solids, liquid orals, semi solids and relevant documentation, SUPAC guidelines, Introduction to platform technology.
19) Quality management systems: Quality management and certification: concept of quality, Total quality management, Quality by Design (QbD), six sigma concept, out of specifications (OOS) change control, Introduction to ISO 9000 series of quality system standards, ISO 14000, NABL.
20) Indian Regulatory Requirements: Central Drug Standard Control Organisation (CDSCO) and State Licensing Authority, Organisation, Responsibilites, Certificate of Pharmaceutical products (COPP) Regulatory requirements and approval procedures for New drugs.
21) Over the counter (OTC) Sales: Introduction and sale of over the counter and Rational use of common over the counter medications.
22) Drug Store Management and Inventory Control: Organisation of Drug Store, types of materials stocked and storage conditions. Purchase and inventory control: Principles, Purchase procedures, Purchase order, Procurement and stocking, Economic order quantity, Reorder quantity level and methods used for the analysis of the drug expenditure.
23) Novel Drug Delivery Systems: Ocular Drug Delivery Systems, Transdermal Drug Delivery Systems, Implantable Newer Drug Delivery Systems, Targeted Drug Delivery and Controlled Drug Delivery Systems.

UNIT II
1) Study of principle, procedure, merits, demerits and applications of physical, chemical, gaseous, radiation and mechanical method of sterilization. Evaluation of the efficiency of sterilization methods. Sterility indicators.
2) Classification and mode of action of disinfectants, factors influencing disinfection, antiseptics and their evaluation, for bacteriostatic and bactericidal actions. Sterility Testing of Products (solids, liquids, Ophthalmic and other Sterile products) according to IP, BP and USP
3) Principles and methods of different microbiological assay. Methods for standardization of Antibiotics, Vitamins and Amino acids.
4) Types of immunity - humoral immunity, cellular immunity
5) Blood products and Plasma Substitutes: Collection, Processing and Storage of whole human blood, dried human plasma, plasma Substitutes Fermentation methods and general requirements, study of media, equipments, sterilization methods, aeration process, stirring. Large scale production fermenter design and its various controls. Study of the production of - Penicillins, Citric acid, Vitamin B12, Glutamic acid, Griseofulvin.
UNIT III :
1) Atomic structure and valency, Radioactivity, Radio isotopes and Pharmaceutical applications of Radio Pharmaceuticals, hazards and precautions.
2) Sources of impurities in Pharmaceutical substances; Limit test as per I.P; Fundamentals of volumetric Analysis. Errors: Sources, types, methods of minimizing errors, Accuracy, Precision, significant figures.
3) A systematic study of inorganic compounds for their preparation, assay and use which includes Gastrointestinal agents, Topical agents and Dental products.
4) Preparation and use of Chemical reagents and Volumetric Solutions as per Pharmacopeia in Pharmaceutical Analysis.
5) Metal hydride reduction, Wolff kishnar reduction, Clemenson’s reduction, Beckmann and Schmidt rearrangement, Oppenauer Oxidation, Claisen-Schmidt condensation.
UNIT IV :
1) Chemistry, synthesis and Medicinal uses of the following categories of drugs - Local Anaesthetics, Drugs acting on CNS, ANS, CVS, Anti-infective agents like Sulphonamides, Antibiotics, AntiTB, Anti- Viral, Antiprotozoal, Antifungal, Antimalarials, Antineoplastic agents, Antihistaminics, Diuretics. 2) QSAR studies, various approaches in drug design.
UNIT V : 1) Principles and Pharmacopeial Assay Procedures involving Non-aqueous Titration, Redox, Diazotization, complexometric methods, electrometric titration, gravimetric analysis.
2) Chromatography- TLC, Column, Paper, GC, Ion exchange, HPLC, HPTLC, Gel electrophoresis.
3) Theory, principle, instrumentation and applications of colorimetry, UV- Visible Spectrophotometry, Spectrofluorimetry, Nepheloturbidometry, IR, Mass, NMR, RIA, Polarimetry, Refractometry, Thermal method of analysis - TGA, DSC, DTA, atomic absorption spectroscopy.
4) ICH guidelines- Calibration and validation, calibration of electronic balance, UV spectrophotometer, IR spectrophotometer, Fluorimeter, HPLC, GC, Flame photometer.
UNIT VI : a. General Pharmacology:- Definition, Sources of drugs, essential drugs concept, routes of drug administration, agonist, antagonist, membrane transport, absorption, distribution, metabolism and excretion of drugs. Enzyme induction, enzyme inhibition. Principles and mechanism of drug action, Classification of receptors, drug receptor interactions, Signal transduction mechanisms, dose response relationship, therapeutic index, combined effects of drug & factors modifying drug action. Adverse drug reactions, Drug interactions, Drug discovery and clinical evaluation of new drugs, Pharmacovigilance.
b. Pharmacology of Drugs acting on central nervous system: General anaesthetics and Pre anaesthetic medication, Sedatives and Hypnotics, centrally acting muscle relaxants, Anti- epileptics, Alcohols and disulfiram, Anti-Psychotics, Anti-depressants, anti-anxiety agents, anti-manics and hallucinogens, Drugs used in Parkinson’s disease and Alzheimer’s disease, CNS-Stimulants and nootropics, Opioid analgesics and antagonists, Drug Addiction, drug abuse, drug tolerance and drug dependence.
c. Pharmacology of Drugs acting on Peripheral nervous system: Neurohumoral transmission in Autonomic nervous system, Para Sympathomimetics, Parasympatholytics, Sympathomimetics, Sympatholytics, neuromuscular blocking agents, Skeletal muscle relaxants (peripheral), Local anaesthetic agents, Drug used in Myasthenia gravis and glaucoma.
d. Pharmacology of Drugs acting on cardio vascular system: Drugs used in congestive heart failure, Anti-hypertensive drugs, Anti-Anginal Drugs, Anti-arrhythmic drugs, Anti-hyperlipidemic drugs, Drugs used in the therapy of shock, Hematinics, Coagulants and anti-coagulants, Fibrinolytics and anti-platelet drugs, Plasma Volume expanders.
e. Pharmacology of drugs acting on urinary system: Diuretics and Anti-diuretics.
f. Pharmacology of drug acting on respiratory system: Anti-asthmatic drugs, Drugs used in the management of COPD [Chronic Obstructive Pulmonary disease], Expectorants, anti-tussives, nasal decongestants, Respiratory Stimulants.
g. Immuno Pharmacology: Immuno sitmulants, immuno suppressants, bio-similars. h. Bio-assay: Principles and applications of Bio-assay, types of bio-assay, bio-assay of insulin, oxytocin, Vasopressin, ACTH, d-tubocurarine, digitalis, histamine and 5 HT. i. Chrono Pharmacology: Definition of rhythm and cycles, Biological clock and it’s significance
UNIT VII : a) Pharmacology of Drugs acting on the Gastrointestinal tract: Anti-ulcer agents, Drugs for constipation and diarrhoea, appetite stimulants and Suppressants, Digestants and carminatives, Emetics and anti-emetics.
b) Pharmacology of drugs acting on endocrine system: Anterior Pituitary hormones – analogues and their inhibitors, Thyroid hormonesanalogues and their inhibitors, Parathormone, Calcitonin, Vitamin-D, Insulin, oral-hypo glycemic agents and glucagon. Adrenocorticotropic hormone [ACTH] and corticosteroids, Androgens and Anabolic Steroids, Estrogens, Progesterone, Oral Contraceptives. Drugs acting on uterus.
c) Autocoids and related drugs: Histamine, 5-HT and their antagonists, Prostaglandins, Thromboxanes and Leukotrienes, Angiotensin, Bradykinin and Substance-P, Non-Steroidal antiinflammatory drugs, Anti- gout drugs, Anti-rheumatic drugs.
d) Chemotherapy: General Principles of chemotherapy, Sulfonamides and co-trimoxazole, Antibiotics: Penicillins, Cephalosporins, Chloramphenicol, macrolides, Quinolones and fluoroquinolones, tetracycline and amino glycosides, Anti-tubercular agents, Anti-leprotic agents, Anti-fungal agents, Anti-viral drugs, Anthelmintics, Antimalarial drugs, Anti-amoebic agents, Urinary tract infection and sexually transmitted diseases, Chemotherapy of malignancy.
e) Principles of toxicology: Acute, Sub-acute, Chronic toxicity, genotoxicity, carcinogenicity, teratogenicity, mutagenicity, General Principles of treatment of poisoning, clinical symptoms and management of barbiturates, morphine, organophosphorus compound, lead, mercury and arsenic poisoning.
UNIT VIII :
a) Alphabetical, Morphological, Taxonomical, Chemical and Pharmacological classification of crude drugs.
b) Adulteration of drugs of natural origin, Evaluation by Organoleptic, Microscopic, Physical, Chemical and Biological methods.
c) Plant hormones and their applications.
d) Types of plant tissue culture, nutritional requirements, growth and their maintenance. Application of plant tissue culture in pharmacognosy.
e) Brief study of basic metabolic pathways and formation of different Secondary metabolites through these pathways - Shikimic acid pathway, Acetate mevalonate pathway.
UNIT IX : a) General introduction, composition, chemistry and chemical classification, general methods of extraction and analysis, bio-sources, therapeutic uses and commercial application of following Secondary metabolites. Alkaloids : Vinca, Rauwolfia, Belladonna, Opium Steroids, Cardiac glycosides and Triterpenoids : Liquorice, Dioscorea, Digitalis Volatile oils : Mentha, Clove, Cinnamon, Fennel, Coriander Tannins : Black & Pale catechu Resins : Benzoin, Ginger, Asafoetida, Colophony Glycosides : Senna, Aloes b) Isolation, Identification & Analysis of following Phytoconstituents
i) Terpenoids : Menthol, Citral, Artemisin ii) Glycosides : Glycyrrhetenic acid, Rutin
iii) Alkaloids : Atropine, Quinine, Reserpine, Caffeine iv) Resins: Podophyllotoxin, Curcumin c) Modern methods of extraction, application of latest techniques like Spectroscopy, Chromatography and Electrophoresis in isolation, purification and identification of Crude drugs. d) Basic principles involved in Homeopathy systems of medicine.
UNIT X :
a) The Drugs and Cosmetics Act, 1940 and Drugs Rules 1945 (As Amended from time to time)
b) The Drugs and Magic Remedies (Objectionable Advertisement) Act, 1954 and Rules, 1955 (As Amended from time to time)
c) The Drugs (Price Control) Order 2013 (As Amended from time to time)
d) The Narcotic Drugs and Psychotropic substances Act and Rules, 1985 (As Amended from time to time)
e) The Pharmacy Act, 1948 (As Amended from time to time)

How to Apply
1. One Time Registration and Online Application: Candidates are required to apply online by using the Commission’s website tnpscexams.in. The candidate needs to register himself / herself first at the One Time Registration (OTR) platform, available Page 3 of 191 on the Commission’s website, and then proceed to fill up the online application for the examination. If the candidate is already registered, he / she can proceed straightway to fill up the online application for the examination.
2. Application Correction Window: After the last date for submission of online application, the Application Correction Window will open for 3 days from 28.08.2024 to 30.08.2024. During this period, candidates will be able to edit the details in their online application. After the last date of the Application Correction Window period, no modification is allowed in the online application.
3. Subject Paper Options: Candidates should choose the subject paper(s) and specify in the online application. The candidates should only choose the subject paper(s) in which they have obtained the educational qualification or equivalent qualification for appearing in the examination.

Important Dates and Time
Last date and time for submission of online application : 24.08.2024 11.59 pm
Application Correction Window period : 28.08.2024 12.01 am to 30.08.2024 11.59 pm
Date and Time of Examination
Paper - I
Subject : Tamil Eligibility Test, General Studies and Aptitude and Mental Ability Test
Date : 26.10.2024
Time : 09.30 am to 12.30 pm
Paper - II
Subject : Clinical Pharmacology (Subject Code 352)
Date : 14.10.2024 to 23.10.2024 (excluding 19.10.2024 and 20.10.2024)
Time : 09.30 am to 12.30 pm